Chlordiazepoxide is a longacting benzodiazepine with anxiolytic, sedative and hypnotic activity. Page 57 safety data sheet according to 19072006ec, article 31 printing date 14. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. It also blocks the acid secretion of the gastrointestinal tract and inhibits the action of nerves that are very active in certain diseases. Chlordiazepoxide exerts its effect by binding to the benzodiazepine site at the gammaaminobutyric. Dispose of by incineration following federal, state, local, or provincial regulations. Search results for chlordiazepoxide at sigmaaldrich. Chlordiazepoxide hydrochloride is 7chloro2methylamino5phenyl3 h1,4benzodiazepine 4oxide hydrochloride. Prescribing information chlordiazepoxide chlordiazepoxide hcl. Identification of the substancemixture and of the companyundertaking 1.
Chlordiazepoxide has depressant effects on the central nervous system. Prescribing information chlordiazepoxide chlordiazepoxide hcl capsules usp 5, 10 and 25 mg pharmacology chlordiazepoxide depresses the cns at the levels of the cortex, the limbic system. Do not use more of it, use it more often, or use it in a different way than directed by your doctor. Antianxiety about this pubmed health uses uses of this medicine. Librax is a prescription medicine that is used with other therapies for the treatment of. Amitriptyline hydrochloride material safety data sheet cas. Warnings chlordiazepoxide hcl may impair the mental andor physical abilities required for the. The drug dosage which effectively blocked the vicious reaction was well below the dose which. Chlordiazepoxide hydrochloride is the prototype for the benzodiazepine compounds. Amitriptyline hydrochloride material safety data sheet cas no. Jan 01, 2017 chlordiazepoxide by mouth klordyeazepoxide hyedroekloride.
This leads to an increase in the opening of chloride channels. Librax chlordiazepoxide hcl clidinium bromide capsules. Chlordiazepoxide affects chemicals in the brain that may be unbalanced. Selected from data included with permission and ed by first databank, inc. Chlordiazepoxide has a medium to long halflife but its active metabolite has a very long half.
Chlordiazepoxide hydrochloride advanced patient information. It usually is taken one to four times a day with or without food. Absorption of oral and intramuscular chlordiazepoxide. Find patient medical information for chlordiazepoxide hcl oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chlordiazepoxide hydrochloride c16h15cl2n3o cid 9916 structure, chemical names, physical and chemical properties, classification, patents, literature. C16h14on3cl a white crystalline conpound, soluble in water.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. As this part of the emedtv site explains, drug interactions with chlordiazepoxide can occur when the drug is taken with certain other drugs, such as antidepressants. Exempt prescription products dea diversion control. Chlordiazepoxide hydrochloride medicinal forms bnf. Nov 09, 2018 chlordiazepoxide is a benzodiazepine benzoedyeazeehpeen. Chlordiazepoxide libritabs, librium daviss drug guide. If not breathing, give artificial respiration and have a trained individual administer oxygen. The dose of chlordiazepoxide hydrochloride will be different for different patients. Warnings chlordiazepoxide hcl may impair the mental andor physical abilities required for the performance of potentially hazardous tasks such as driving a vehicle or operating machinery. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves.
Chlordiazepoxide is used to relieve symptoms of anxiety, including nervousness or anxiety that happens before a surgery. Chlordiazepoxide hydrochloride exhibits no optical activity. Chlordiazepoxide definition of chlordiazepoxide by the free. Chlordiazepoxide hcl capsules are contraindicated in patients with known hypersensitivity to the drug. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. Chlordiazepoxide hydrochloride capsules, usp gelatin coated. Librium chlordiazepoxide is among the safer of the effective psychopharmacologic compounds available, as demonstrated by extensive clinical evidence. Sigmaaldrich material safety data sheet date printed. Chlordiazepoxide hydrochloride capsules, usp, the original chlordiazepoxide hydrochloride and prototype for the benzodiazepine compounds, was synthesized and developed at hoffmannla roche. Chlordiazepoxide hydrochloride chlordiazepoxide hydrochloride capsule barr laboratories inc. Chlordiazepoxide is a benzodiazepine benzoedyeazeehpeen.
Chlordiazepoxide definition of chlordiazepoxide by the. Synonyms chlordiazepoxide hcl unii mfm6k1xwdk cas number 438415 weight average. Each capsule also contains corn starch, lactose and talc. May cause eye, skin, or respiratory system irritation. Chlordiazepoxide hydrochloride capsules, usp, the original chlordiazepoxide hydrochloride and prototype for the benzodiazepine compounds, was synthesized and developed at hoffmannla roche inc. Chlordiazepoxide hydrochloride monograph for professionals. Butalbital, acetaminophen and caffeine capsules usp 5030040. Chlordiazepoxide hydrochloride and clidinium bromide capsules contain not less than 90.
Each capsule, for oral administration, contains either 5 mg, 10 mg or 25 mg of chlordiazepoxide hydrochloride, usp and has the following inactive ingredients. Identification of the substancemixture and of the companyundertaking product name. Amitriptyline hydrochloride material safety data sheet. Prescribing information chlordiazepoxide chlordiazepoxide hcl capsules usp 5, 10 and 25 mg anxiolytic aa pharma inc. Similarly, it may impair mental alertness in children.
Chlordiazepoxide, trade name librium among others, is a sedative and hypnotic medication of the benzodiazepine class. Follow your doctors orders or the directions on the label. Wholeblood concentrations of chlordiazepoxide cdx and its first active metabolite, desmethylchlordiazepoxide. Each capsule, for oral administration, contains either 5 mg, 10 mg or 25 mg of chlordiazepoxide hydrochloride usp and has the following inactive ingredients. Find out information about chlordiazepoxide hydrochloride. Chlordiazepoxide exerts its effect by binding to the benzodiazepine site at the gammaaminobutyric acid gaba receptor chloride ionophore complex in the central nervous system cns.
Medications which have similar activity may increase the risk for drowsiness, respiratory depression, and other cns depressant. Chlordiazepoxide and clidinium may be habitforming. Librium chlordiazepoxide is available as capsules containing 5 mg, 10 mg or 25 mg chlordiazepoxide hci. This ed material has been downloaded from a licensed data provider and is not for distribution, except. In study one, single 50mg doses of cdx hcl were administered orally and by i.
Chlordiazepoxide comes as a tablet and capsule to take by mouth. Chlordiazepoxide hydrochloride measured between 360 and 210 nm in acidified 3a alcohol exhibits maxima at 245246 nm and 3112 nm. Chlordiazepoxide hydrochloride capsules usp civ rx only description chlordiazepoxide hydrochloride is the prototype for the benzodiazepine compounds. Librax chlordiazepoxide hydrochlorideclidinium bromide. It may also be used to treat symptoms of alcohol withdrawal. Chlordiazepoxide by mouth national library of medicine. Chlordiazepoxide libritabs, librium is indicated for the relief of acute agitation and hyperactivity e. Take chlordiazepoxide hydrochloride only as directed by your doctor. Hazards identification classification of the substance or mixture signal word. Chlordiazepoxide hydrochloride c16h15cl2n3o pubchem. Therefore, coadministration with alcohol, kava kava, other benzodiazepines, and opiates should generally be avoided. It is a versatile therapeutic agent of proven value for the relief of anxiety. Each capsule, for oral administration, contains either 5 mg, 10 mg or 25 mg of chlordiazepoxide hydrochloride, usp and has the following inactive. Chlordiazepoxide hydrochloride capsules, usp gelatin.
Medications which have similar activity may increase the risk for drowsiness, respiratory depression, and other cns depressant effects. Treats anxiety, symptoms of alcohol withdrawal, and tremor. Librax is available in light green opaque capsules, each containing 5 mg chlordiazepoxide hydrochloride and 2. The differential scanning calorimetry spectrum of chlordiazepoxide hydrochloride is shown. Chlordiazepoxide hazardous combustion products thermal decomposition or combustion products may include the following substances. Perform a hazardous waste determination on mixtures.
Carbon oxides, nitrogen oxides n ox, hydrogen chloride gas 5. Oct 22, 2019 take chlordiazepoxide hydrochloride only as directed by your doctor. Chlordiazepoxide hydrochloride and clidinium bromide librax combines the antianxiety action of chlordiazepoxide and the antispasmodic effects of clidinium. Material may be irritating to the mucous membranes and upper respiratory tract. Chlordiazepoxide 10mg capsules phoenix healthcare distribution ltd schedule 4 cd benz active. Empirical formula hill notation c 16 h 14 cln 3 o hcl. Librium is available as capsules containing 5 mg, 10 mg or 25 mg chlordiazepoxide hcl. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or if you have. Nov 04, 2019 on the basis of molecular weight, 89 mg of chlordiazepoxide is equivalent to 100 mg of chlordiazepoxide hydrochloride. If breathing is difficult, have a trained individual administer oxygen. Each trazodone hydrochloride tablets intended for oral administration contains trazodone.
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